Exemestane 25mg per ml 30ml
Exemestane prevents aromatase enzymes converting androgen to estrogen:
- 95% protein binding with a half-life of 27 hours
- Before each administration, agitate the bottle
- Not for human consumption
Exemestane, is one of the compounds in the group known as aromatase inhibitors. Aromatase is an enzyme that synthesizes hormones. Aromatase inhibitors prevent the synthesis estrogen. The irreversible aromatase inhibitor, exemestane, is structurally related with the natural substrate androstenedione. It is used as a false substrate by the aromatase enzyme and is then processed to an intermediate which binds irreversibly with the enzyme’s active site, causing its activation
Of note: The estrogen suppression rate for Exemestane varies from 35% for estradiol (E2) to 70% for estrone (E1).
It reduces levels of circulating estrogen that is found in animal test subjects. Although the ovaries are the primary source of estrogen postmenopausal, estrogen comes from the aromatization androstenedione/testosterone. Aromatase is a member the cytochrome P-450 family. Aromatase can be found in the liver, adrenal glands, and fat tissue.
Exemestane is similar to androstenedione. It can compete with testosterone and androstenedione. It forms covalent bonds to the enzyme’s substrate-binding component. This causes irreversible aromatase activation.
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