Tamoxifen Citrate 20mg per ml 30ml
Tamoxifen, a selective estrogen receptor modulator, plays a crucial role in inhibiting the growth of estrogen receptor-positive tumors and promoting apoptosis. Its long duration of action, attributed to the active metabolite N-desmethyl tamoxifen, which has a half-life of around 2 weeks, makes it a potent anti-cancer drug. However, its therapeutic index is narrow, and higher doses can lead to breathing difficulty or convulsions. Additionally, tamoxifen administration has been linked to an increased incidence of uterine malignancies. Domestic Peptides offers Tamoxifen Citrate 20mg per ml 30ml that is high-quality.
Apart from competitively inhibiting estrogen binding to its receptor, tamoxifen leads to a decrease in tumor growth factors a and insulin-like growth factor 1, while increasing sex hormone-binding globulin levels. This, in turn, limits the amount of freely available estradiol, leading to a decrease in factors that stimulate tumor growth.
Furthermore, tamoxifen has been found to induce apoptosis in estrogen receptor-positive cells by inhibiting protein kinase C, preventing DNA synthesis, or inducing tumor growth factor b. These actions contribute to its effectiveness as an anti-cancer drug, but caution must be taken with dosing and monitoring for potential adverse effects.
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